What should I do about uncommon pathogens like Vibrio?

Shotgun sequencing can detect rare or unexpected microbes, including Vibrio, Aeromonas, and other environmental organisms.

Interpretation framework:

• High abundance + GI symptoms → Consider true infection, particularly with exposure history (seafood, travel, contaminated water)
• Low abundance + no symptoms → Potentially transient exposure or environmental contamination

Always integrate with:

• Clinical presentation (diarrhea, fever, dehydration)
• Exposure and travel history
• Concurrent lab findings (inflammatory markers, blood in stool)